SUSPECT is a prospective, single-center, cohort study of 250 military aircrew at the Center for Man in Aviation, Royal Netherlands Air Force. All asymptomatic aircrew (≥40 years) are asked to undergo a coronary CT scan on a voluntary basis, following the exercise electrocardiograms performed at their routine aeromedical examination. Coronary Artery Calcium score (CACS) and CCTA findings are reported.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
SCREENING
Masking
NONE
Enrollment
250
A CTA will be performed on asymptomatic individuals
A routine exercise stress test will be performed on a bicycle
Center for Man in Aviation
Soesterberg, Utrecht, Netherlands
Utrecht University Medical Center
Utrecht, Netherlands
Determine the prevalence and severity of CAD in asymptomatic air crew using CCTA as a primary screening tool
Time frame: 8 Years
Determine the diagnostic accuracy of clinically relevant CAD of the exercise stress test versus CCTA
Both modalities are used to track down clinically relevant CAD. Clinically relevant CAD is defined as a stenosis of \>50%.
Time frame: 8 Years
Compare the incidence of Major Adverse Cardiac Events (MACE) and all-cause mortality in populations screened between primary and secondary screening after 12 months
Time frame: 8 Years
Compare the incidence of coronary angiograms and revascularization procedures in the population screened with CTA compared to a historical population using CTA as a secondary screening tool
Time frame: 8 Years
Establish the additive value of coronary artery calcium score (CACS) in addition to clinical risk scores as a predictor of CAD on CCTA
Time frame: 8 Years
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