This is a study of LY3484356 in Chinese participants with advanced breast cancer. Participants must have breast cancer that is estrogen receptor positive (ER+), HER2 negative (HER2-). The purpose of this study is to measure how much LY3484356 gets into the bloodstream and how long it takes the body to remove it. The safety and effectiveness of LY3484356 will also be studied. Participation could last up to 28 months.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
17
Administered orally.
Wannan Medical College Yijishan Hospital
Wuhu, Anhui, China
Hunan Cancer Hospital
Changsha, Hunan, China
The Third Hospital of Nanchang
Nanchang, Jiangxi, China
Fudan University Shanghai Cancer Center
Shanghai, Shanghai Municipality, China
Pharmacokinetics (PK): Plasma Concentration of LY3484356
PK: Plasma Concentration of LY3484356
Time frame: Time Frame: Cycle 1, Day 1 through Day 3 and Day 17 through Day 18; Cycle 2 Day 1 (Cycle 1 = 30 days, Cycle 2 = 28 days)
2. Percentage of Participants Who Achieve a Best Overall Response (BOR) of Complete Response (CR) or Partial Response (PR): Overall Response Rate (ORR)
ORR
Time frame: Randomization to Disease Progression or Death from Any Cause (Estimated up to 28 months)
Disease Control Rate (DCR): Percentage of Participants With a BOR of Complete Response (CR), Partial Response (PR) or Stable Disease (SD)
DCR
Time frame: Randomization to Disease Progression or Death from Any Cause (Estimated up to 28 months)
Progression-Free Survival (PFS)
PFS
Time frame: Randomization to Disease Progression or Death from Any Cause (Estimated up to 28 months)
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.