Genetic Biomarkers Associated With Child Language Development in Taiwan (II)

Chang Gung Memorial Hospital115 enrolled

Overview

A study of the relation between genetic biomarkers and child language development in Taiwan.

The interaction between gene and environment (G×E) can be a very complicated process that influences child development. As a pilot study of child development biomarkers, this study investigates genes related to child language development and language disorder.

Study Type

OBSERVATIONAL

Enrollment

115

Conditions

Child Language

Interventions

The research does not require interventionsGENETIC

We use Whole-exome sequence (WES) to analyze if there is any gene mutations for DLD(developmental language disorder) children.

Eligibility

Sex: ALLMin age: 2 YearsMax age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age 2-18 y/o * Agree to sign informed consent Exclusion Criteria of Healthy Child: * Central nervous system disease * Neuromuscular Disorders * Congenital Abnormality * Genetic Disease * Dysesthesia * Hearing Impairment Inclusion Criteria of Child with language disorder: * Patients with Language Disorder * Age 2-18 y/o * Agree to sign informed consent Exclusion Criteria of Child with language disorder: * Hearing Impairment * Inclusion Criteria of Adult: * His or her child participated in this study, and gene abnormality was found.

Locations (1)

Chang Gung Memoria Hospital

Taoyuan District, Taiwan

Outcomes

Primary Outcomes

Scores of cognitive function 1

Bayley Scales of Infant and Toddler Development (Scores from 0 to 140, higher scores mean a better outcome.)

Time frame: baseline

Scores of cognitive function (2 y/o to 6 y/o)

Wechsler Preschool and Primary Scale of Intelligence (Scores from 0 to 200, higher scores mean a better outcome.)

Time frame: baseline

Scores of cognitive function (6 y/o to 16 y/o)

Wechsler Intelligence Scale for Children (Scores from 0 to 200, higher scores mean a better outcome.)

Time frame: baseline

Scores of cognitive function 3

Test of Nonverbal Intelligence-Fourth Edition (Scores from 0 to 60, higher scores mean a better outcome.)

Time frame: baseline

Scores of language function 1

Peabody Picture Vocabulary Test-Revised (Scores from 0 to 124, higher scores mean a better outcome.)

Time frame: baseline

Scores of language function 2

Preschool Language Impaired Scale(PLS)/Language Impaired Scale(LS) (PLS: Scores from 0 to 65, higher scores mean a better outcome. LS: Scores from 0 to 73, higher scores mean a better outcome.)

Time frame: baseline

Scores of general development

Comprehensive Developmental Inventory for Infants and Toddlers (Higher scores mean a better outcome.) Applied for children aged 3-71 months. Assessing areas: Cognition, language, motor, social, and self-care skills. Every item is scored 0 or 1, indicating whether the child 'fails' or 'passess' that item.

Time frame: baseline

Data from ClinicalTrials.gov

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Secondary Outcomes

Scores of participation(2-5 y/o)

Assessment of Preschool Children's Participation (Scores from 0 to 45, higher scores mean a better outcome.)

Time frame: baseline

Scores of participation(>6 y/o)

Children Assessment of Participation and Enjoyment and Preferences for Activity of Children (Higher scores mean a better outcome.)

Time frame: baseline

Scores of activities

Functional Independence Measure for Children (Scores from 18 to 126, higher scores mean a better outcome.)

Time frame: baseline

Scores of quality of life

Pediatric Quality of Life Inventory TM (Scores from 0 to 102, higher scores mean a better outcome.)

Time frame: baseline