Parkinson's disease is a chronic, neurodegenerative disorder characterized with the loss of dopamine-producing neurons. This loss is likely to be related with several environmental and genetic factors. One of the most important factor that is responsible for the initation and progression of the disease is oxidative stress. Exercise training, especially aerobic training, can change the levels of oxidative markers because exercise can lead to decrease oxidative stress in patients with Parkinson's disease. Therefore, this study aims to investigate (1) the effect of aerobic training on total antioxidant status, total oxidant status, glutathione, oxidative glutathione, and zonulin levels, (2) the relationship between the change of motor symptoms and disease severity and the change of total antioxidant status, total oxidant status, glutathione, oxidative glutathione, and zonulin levels.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
28
People with Parkinson's Disease will be received a supervised physiotherapy and rehabilitation program.
Saglik Bilimleri Universitesi
Ankara, Turkey (Türkiye)
Total antioxidant status
Total antioxidant status is an important marker of total antioxidant capacity and it indicates an overall measure for the cumulative action of all antioxidants.
Time frame: 10 minutes
Total oxidant status
Total oxidant status is an significant marker of total oxidant capacity and it indicates an overall measure for the cumulative action of all oxidants.
Time frame: 10 minutes
Glutathione
Glutathione is an important intracellular antioxidant that protects against a variety of different antioxidant species.
Time frame: 10 minutes
Oxidative glutathione
Oxidative glutathione generated by glutathione reductase should be provided as decreased glutathione to the site.
Time frame: 10 minutes
Zonulin
The levels of zonulin can reflect systemic inflammation and oxidative stress.
Time frame: 10 minutes
Movement Disorders Society Unified Parkinson's Disease Rating Scale
The Movement Disorders Society Unified Parkinson's Disease Rating Scale is the most commonly used scale to assess disease severity in Parkinson's Disease. It consists of four parts: (1) non-motor experiences of daily living, (2) motor experiences of daily living, (3) motor examination, and (4) motor complications.
Time frame: 15 minutes
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