The Effects of NSAIDs on Bone Metabolism Following Exercise

Inclusion Criteria: * Must currently exercise at least 2 times per week * Must be willing to discontinue the use of nutritional supplements, alcohol and nicotine during each study period (4 trials of 5 consecutive days each), unless approved by PI * Must be willing to refrain from taking NSAIDs and similar medications during the course of the study (other than those given by the study team) * Weigh at least 110 lbs and have a hemoglobin of 12.5 g/dL or higher Exclusion Criteria: * Known allergic reaction to any NSAID type medication * History of gastrointestinal disorders/discomfort associated with or which may be aggravated with NSAID use * History or known gastric ulcer * History of endocrine disorders (e.g., diabetes, uncontrolled thyroid dysfunction, hypoparathyroidism, or hyperparathyroidism) * History of bone-modifying disorder (e.g., osteogenesis imperfecta, osteoporosis, or rickets) * Diagnosed bone fracture within last 6 months * History of cardiovascular or renal diseases * Pregnant or lactation in the last 6 months * Currently taking or history of routine use of medications known to affect bone or calcium metabolism (e.g., thiazide diuretics, bisphosphonates, oral steroids) * History of back or shoulder injury which may be aggravated by exercise * Blood donation within 8 weeks of the study * Current physical illness or injury limiting physical activity * Known allergy to lidocaine