Screening for Neurodevelopmental Disorders in Siblings of Children With Autism Diagnosed in Tertiary Centers

University Hospital, Montpellier384 enrolled

Overview

In this study, a selective and multi-stages screening for neurodevelopmental disorders (NDD) in siblings of children with a confirmed ASD is done. The main aims are to estimate the prevalence of NDD among siblings and to evaluate the feasibility and acceptability of a standardized screening procedure.

Although NDD are frequent among siblings of children with ASD, their developmental screening is not yet sufficiently organized in routine practice. The needs and the characteristics of these siblings have yet to be better understood in order to define their developmental surveillance.

Study Type

OBSERVATIONAL

Enrollment

384

Conditions

Autism Spectrum Disorder Siblings Neurodevelopmental Disorders

Interventions

Step 1 - Screening ; Step 2 - Clinical interviewDIAGNOSTIC_TEST

Step 1: screening is performed by online parental questionnaires (SRS-2, Identidys scale, DCDQ, parental concerns questionnaire ) via a web platform. Parents and registered doctors will be informed by mail in case of negative screening; In case of positive screening, they will be called by phone in order to give them the results and to invite them for a clinical and semi-structured interview. Step 2: The semi-structured interview will be performed by a psychologist specialized in NDD in order to clinically confirm the results of the screening and refer the child to care and interventions, by mail to the registered doctor. Around 12 months after this interview, parents will be called by phone to collect a description of the referral and their satisfaction about the screening process.

Eligibility

Sex: ALLMin age: 2 YearsMax age: 16 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Step 1: Brothers or sisters (including stepsisters and brothers); aged between 2 and 16 years; living in Occitanie; informed and express consent of parents ; affiliated to social security. * Step 2: step 1 positive screening or parental concerns for child's development ; parental signed informed consent. Exclusion Criteria: * Parents (or child) refusal to participate; adopted brother or sister. Do not speak French

Locations (1)

Chu Montpellier

Montpellier, France

RECRUITING

Outcomes

Primary Outcomes

Percentage of family participation

Families' participation rate and, among participants, number of children with a NDD diagnosis at the end of the screening study.

Time frame: 12 months

Secondary Outcomes

Sensibility, specificity, positive predictive values (PPV) and negative predictive values (NPV) of the screening procedure

Time frame: 12 months

Percentage of satisfied parents

Estimate the level of satisfaction of parents who participated in the screening with the parental satisfaction score via the Visual Analog Scale (VAS). VAS is a scale from 0 (not at all satisfied) to 100 (very satisfied)

Time frame: 12 months

Central Contacts

Cécile MICHELON

CONTACT

467330986 c-michelon@chu-montpellier.fr

Charlotte GERBE

CONTACT

charlotte.gerbe@chu-montpellier.fr

Data from ClinicalTrials.gov

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