The aim of this prospective randomized-control study was to evaluate the impact of a single high-dose intravenous vitamin C added to ultrasound-guided blocks at induction on postoperative pain, sngception and early functional rehabilitation of the knee joint in patients under-going total knee arthroplasty.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
73
Intravenous loading of 100mg/kg ascorbic acid with normal saline, totally 100ml Completed before induction
Intravenous loading 100ml normal saline
Chi Mei Medical Center
Tainan, Tainan City, Taiwan
Numeric rating scale for pain
11-point numeric scale ranges from '0' representing no pain to '10' representing the extreme pain
Time frame: 15 minutes postoperatively
Numeric rating scale for pain
11-point numeric scale ranges from '0' representing no pain to '10' representing the extreme pain
Time frame: 1 hour postoperatively
Numeric rating scale for pain
11-point numeric scale ranges from '0' representing no pain to '10' representing the extreme pain
Time frame: 6 hours postoperatively
Numeric rating scale for pain
11-point numeric scale ranges from '0' representing no pain to '10' representing the extreme pain
Time frame: 24 hours postoperatively
Numeric rating scale for pain
11-point numeric scale ranges from '0' representing no pain to '10' representing the extreme pain
Time frame: 48 hours postoperatively
Numeric rating scale for soreness (Sngception)
11-point numeric scale ranges from '0' representing no soreness to '10' representing the extreme soreness
Time frame: 15 minutes after surgery
Numeric rating scale for soreness (Sngception)
11-point numeric scale ranges from '0' representing no soreness to '10' representing the extreme soreness
Time frame: 1 hours postoperatively
Numeric rating scale for soreness (Sngception)
11-point numeric scale ranges from '0' representing no soreness to '10' representing the extreme soreness
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Time frame: 6 hours postoeratively
Numeric rating scale for soreness (Sngception)
11-point numeric scale ranges from '0' representing no soreness to '10' representing the extreme soreness
Time frame: 24 hours postoperatively
Numeric rating scale for soreness (Sngception)
11-point numeric scale ranges from '0' representing no soreness to '10' representing the extreme soreness
Time frame: 48 hours postoperatively
Morphine consumption
Amount of IV morphine consumption postoperatively
Time frame: 48 hours postoperatively
Time to first rescue morphine requirement at post-anesthetic care unit
Duration from arriving post-anesthetic care unit to requiring first morphine injection
Time frame: up to 2 hours
Severity of postoperative nausea/ vomiting and dizziness
From 0 to 5, 0: non, 1: mild, 2: moderate, 3: severe, 4: unbearable
Time frame: 48 hours postoperatively