This 12-months long pilot study will include patients undergoing an endoscopic procedure (endoscopic sleeve gastroplasty \[ESG\] or transoral outlet reduction \[TORe\]) as clinically indicated, and subsequent follow up clinic visits for up to one year.
The purpose the research is to better understand the effects of endoscopic bariatric therapy (EBT) on the weight change, hormonal changes and changes in the quality of life parameters for patients undergoing endoscopic bariatric procedures. The primary research procedures are: * EBT procedure (endoscopic sleeve gastroplasty \[ESG\] or transoral outlet reduction \[TORe\]) * Behavioral intervention consisting of diet therapy, exercise therapy, and behavior modification * Collection of blood to evaluate changes in hormonal profiles
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
20
Endoscopic sleeve gastroplasty or transoral outlet reduction
Liliana Bancila
Los Angeles, California, United States
RECRUITINGChanges in body weight after various endoscopic bariatric therapies
The investigators will compare mean percentage total body weight loss to baseline, at 1 month, 3 months, 6 months and 1 year post procedure.
Time frame: Baseline/pre-procedure, 1 month, 3 months, 6 months, and 1 year post procedure
Changes in hormonal profiles after various endoscopic bariatric therapies
Repeated blood draws will be performed, and the following hormones will be measured: ghrelin, glucagon-like peptide 1 (GLP-1), peptide YY (PYY), gastric inhibitory polypeptide (GIP), and oxyntomodulin. We will compare changes over time in hormonal levels after EBT to baseline, 3 months, and 6 months post-procedure.
Time frame: Baseline/pre-procedure, 3 months, 6 months
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