Influence of Shenqu Xiaoshi Oral Liquid on Intestinal Microbiome of Children With Functional Dyspepsia

Inclusion Criteria: 1. Outpatients aged 3-14 years old; 2. Meeting ≥1 condition(s): (1)Postprandial fullness;(2)early satiation;(3)Epigastric pain or burning not associated with defecation; 3. Having symptoms at least 2 months and at least 4 days per month before diagnosis; 4. During the 2-wk lead-in period, no relevant drugs for the treatment of dyspepsia and anorexia were used, good eating habits have been established, and the FD symptoms still existed (symptom score≥3). 5. Informed consent was obtained from the parents/guardians of the participant. If the child was more than 8 years old, additional informed consent would be required from the participant. Exclusion Criteria: 1. Anorexia and dyspepsia caused by certain drugs and confirmed organic diseases such as erosive gastritis, peptic ulcer, etc; 2. Severe malnutrition; 3. Serious primary diseases of the cardiovascular, nervous, respiratory, hepatobiliary and endocrine systems; 4. Mental disorders, intellectual disabilities, and/or communication impairments; 5. Lactose intolerant or allergic to the ingredients of Shenqu Xiaoshi Oral Liquid or Traditional Chinese medicine; 6. Probiotics or antibiotics within 4-wk; 7. Participated in a clinical trial within the past 12-wk; 8. Individuals deemed unsuitable for this clinical trial.