The investigators are suggtesting that lower goals of systolic blood pressure after intravenous thrombolysis may reduce the risk of hemorrhagic complications and improve functional outcomes after acute ischemic stroke.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
90
Different hemodynamic goals in different study arms
City Hospital # 1 n.a. E.E. Volosevich
Arkhangelsk, Russia
Modified Rankin Scale score
Fucntional outcome (Modified Rankin Scale) will be assesed by telephone interview. Score from 0 to 6. Higher scores mean a worse outcome.
Time frame: 90 day after intravenous thrombolysis
Mortality rate
Time frame: At 90 day after intravenous thrombolysis
Rate of symptomatic intracranial hemorrhage
Symptomatic intracranial hemorrhage (sICH) according to SITS-MOST study description of sICH
Time frame: 24 hours after intravenous thrombolysis
Rate of symptomatic intracranial hemorrhage
Symptomatic intracranial hemorrhage (sICH) according to SITS-MOST study description of sICH
Time frame: 7 days after intravenous thrombolysis
Change in National Institutes of Health Stroke Scale (NIHSS)
Score form 0 to 42. Higher score indicates worse outcome
Time frame: at 28 day after intravenous thrombolysis
Rate of all Intracranial hemorrhage
Intracranial hemorrhage will be classified according to Heidelberg bleeding classification
Time frame: 24 hours after intravenous thrombolysis
Rate of all Intracranial hemorrhage
Intracranial hemorrhage will be classified according to Heidelberg bleeding classification
Time frame: 7 days after intravenous thrombolysis
Lengths of stay in ICU
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Time frame: at 90 day after intravenous thrombolysis
Lengths of stay in hospital
Time frame: at 90 day after intravenous thrombolysis
Rate of acute kidney injury
Acute kidney injury will be assesed according to RIFLE Classification
Time frame: 28 day after intravenous thrombolysis or at discharge