The Safety and Efficacy Study of Avatrombopag Switch in TPO-RA Refractory AA

Inclusion Criteria: Subjects eligible for inclusion in this study must meet all of the following criteria: 1. Patients with confirmed TDNSAA/SAA/VSAA aplastic anemia who received standard IST therapy for at least 6 months, combined with Haitrombopag (15mg/d) or Eltrombopag (\>50mg/d) for at least 3 Patients who have not obtained a hematological response (NR) for months and are not suitable or unwilling to undergo HSCT 2. Age \> 14 years old, male or female. 3. Subjects must complete all screening assessments listed in the trial protocol. 4. ECOG score ≤ 2 points. 5. Before the start of the research procedure, the patient or guardian should fully understand the research procedure and purpose and sign the informed consent form. If the patient's signature is not conducive to the treatment of the disease, the patient's immediate family should sign the informed consent form. Exclusion Criteria: Subjects meeting any of the following criteria were excluded from this study: 1. Patients with severe infectious diseases (uncured tuberculosis, pulmonary aspergillosis, various bacterial and viral infections) and active bleeding that cannot be controlled after standard treatment. 2. Patients with AIDS, active viral hepatitis B, and hepatitis C RNA nucleic acid test positive. 3. Those who are pregnant or breastfeeding, have fertility but are unwilling to take effective contraceptive measures. 4. Congenital hematopoietic failure diseases (such as Fanconi anemia). 5. Patients with cytogenetic clonal changes (excluding germline mutations and acquired chromosome clones of +8, 20q- and -y). 6. Combined with malignant tumor within 3 years. 7. Combined with other systemic diseases that cannot be controlled. 8. Significant abnormalities in cardiopulmonary function. 9. Abnormal liver and kidney function: creatinine level \> 1.5 times the upper limit of normal, transaminase and bilirubin level \> 2 times the upper limit of normal, and those who cannot be enrolled in the group as judged by the clinician. 10. Those who are considered unsuitable for enrollment by the investigator.