Effect of Probiotics as Supplement to Non-surgical Periodontal Treatment

University of Copenhagen60 enrolled

Overview

The present study is a double-blinded randomized clinical trial with a duration of 12 weeks.

The present study is a double-blinded randomized clinical trial with a duration of 12 weeks . 60 patients with periodontitis stage 2-3, grade B-C, generalized will be allocated in the test (probiotic) and the control (placebo) group at baseline. The intervention is non-surgical periodontal treatment, which will be applied at baseline and followed for 12 weeks. Clinical measurements and sampling will be performed at baseline, week 6 and week 12. Primary endpoint: Changes in microbial composition. Secondary endpoints: Changes in clinical and immunological parameters

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

Conditions

Periodontitis

Interventions

ProbioticDIETARY_SUPPLEMENT

In this group participants will receive probiotic supplements twice a day (morning and evening) for a period of 12 weeks.

PlaceboDIETARY_SUPPLEMENT

In this group participants will receive placebo twice a day (morning and evening) for at period of 12 weeks.

Eligibility

Sex: ALLMin age: 30 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Periodontitis stage 2-3, Grade B-C, generalized Exclusion Criteria: * • Use of systemic antibiotics within the latest three months.

Locations (1)

University of Copenhagen, Department of Odontology

Copenhagen, Denmark

RECRUITING