Treatment of Recurrent Pregnancy Loss Using Mesenchymal Stem Cells

Inclusion Criteria: * female patients of reproductive age 18-49 years; * recurrent pregnancy loss without current pregnancy with thin endometrium; * unsuccessful IVF cycles due to thin endometrium; * endometrial thickness is ≤6 mm in the first and second phases of the menstrual cycle; * uterine infertility associated with endometrial hypoplasia; * the absence of genetic diseases that prevent pregnancy; * absence of taking hormonal drugs for 3 months prior to enrollment in the study. Exclusion Criteria: * patients with congenital malformations of the genital organs: agenesis and aplasia of the uterus, bicornuate uterus, unicornuate uterus, congenital fistula between the uterus and the digestive and urinary tracts, other congenital anomalies of the body and cervix. congenital anomaly of the body and cervix, unspecified, other specified developmental anomalies; * acute inflammatory processes in the uterus; * acute or chronic infectious and non-infectious diseases in the acute stage, including HIV, hepatitis B and C, syphilis, tuberculosis, chlamydia, myco-, ureaplasmosis, herpes, toxoplasmosis, rubella, cytomegalovirus, gonorrhea, trichomoniasis, etc.; * autoimmune diseases; * patients with malignant tumor including a history; * patients with benign tumors of the uterus and appendages; * miscarriage not associated with a thin endometrium, including immunological origin; * hyper- or hypogonadotropic insufficiency of ovarian function, hyperandrogenemia of any origin; * allergic reactions in the acute stage, established hypersensitivity to any component of the biomedical cell product; * permanent therapy with cytostatics, hormones; * mental and behavioral disorders that make it impossible for patients to participate in the study, drug and/or alcohol addiction.