The aim of this study is to understand why patients with obsessive-compulsive disorder (OCD) fail in therapy. To understand the neural mechanisms involved in exposure therapy that support success and clinical improvement in order to improve therapy outcomes for OCD patients.
A course of therapy is recommended for individuals with obsessive-compulsive disorder (OCD). It is usually a type of cognitive behavioural therapy (CBT) with exposure and response prevention (ERP). In this study the investigators assess patients pre-therapy and post-therapy evaluating symptom severity (measured by the Y-BOCS) and decision-making (measured by online questionnaires and computer-based behavioural tasks). To examine how decisions are formed in patients undergoing OCD CBT, how behaviour changes after a non-pharmacological therapy module and how it is associated to the alleviation of OCD symptoms. The study, which will recruit 90 patients, is based at University College London - Wellcome Centre for Human Neuroimaging. This study is a part of the Cognitive and Neural Networks in Psychiatry (CNNP) study.
Study Type
OBSERVATIONAL
Enrollment
90
Max Planck UCL Centre for Computational Psychiatry and Ageing Research
London, United Kingdom
RECRUITINGYale-Brown obsessive compulsive scale (Y-BOCS)
The Y-BOCS is a 10-item scale used to assess symptom severity in OCD.
Time frame: 3 - 9 months
Decision making and learning tasks
Computer-based behavioural task developed by the investigators to understand decision making in OCD.
Time frame: 3 - 9 months
Patient EX/RP Adherence Scale (PEAS)
Self-report assessment for patient's therapy adherence.
Time frame: 3 - 9 months
Short form of Obsessive Beliefs Questionnaire (OBQ)
Self-report assessment for obsessive beliefs.
Time frame: 3 - 9 months
Brief Experiential Avoidance Questionnaire (BEAQ)
Self-report assessment for experiential avoidance.
Time frame: 3 - 9 months
International Cognitive Ability Resource (ICAR16)
Measure to assess cognitive ability.
Time frame: 3 - 9 months
Worry Domains Questionnaire - Short Form (WDQ-SF)
Self-report assessment for worry.
Time frame: 3 - 9 months
The World Health Organization Quality of Life Brief Version (WHOQOL-BREF)
Self-report assessment for quality of life assessment.
Time frame: 3 - 9 months
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Sheehan Disability Scale (SDS)
Self-report assessment for functional impairment.
Time frame: 3 - 9 months
State-Trait Anxiety Inventory (STAI)
Measure of trait and state anxiety
Time frame: 3 - 9 months
Zung Self-Rating Depression Scale (SDS)
Self-report measure of depressive symptomatology.
Time frame: 3 - 9 months
Anxiety Sensitivity Index (ASI-3)
Self-report measure for anxiety sensitivity symptomatology.
Time frame: 3 - 9 months