This study intends to study the optimal dose induced by etomidate in outpatients undergoing painless hysteroscopic surgery. At present, the dosage in the user manual is 0.1-0.3mg/kg. In clinical use, it is found that 0.1mg/kg often fails to achieve sedative effect, and 0.3mg/kg is prone to muscle twitching. Therefore, three groups of doses of 0.15mg/kg, 0.2mg/kg and 0.25mg/kg are set. It is hoped that this study will provide a basis for clinical evaluation of etomidate in anesthesia induction of hysteroscopic surgery.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
200
Mean Arterial Pressure
Mean value of Mean Arterial Pressures
Time frame: Change in Mean Arterial Pressure(MAP) in mm of Hg from baseline value every 5 minutes for 30 minutes
Heart rate per minute
Mean of Heart rate per minute at above mentioned time intervals was measured and any study drug causing bradycardia
Time frame: Change in Heart rate per minute from baseline value every five minutes for 30 minutes
Myoclonic movements
% of cases with Myoclonic movements
Time frame: 60 seconds after injection of study drug
Post Operative Nausea and Vomiting
% of cases with any treatment for Post Operative Nausea and Vomiting
Time frame: Throughout entire study estimated to take 1 month to complete
any oxygen saturation event below 85% by pulse oximetry
% of cases with any oxygen saturation event below 85% by pulse oximetry
Time frame: Throughout entire study estimated to take 1 month to complet
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