Asymptomatic Bacteriuria, Urinalysis Abnormality at the Initiation of SGLT2 Inhibitors and UTI Risk

N/AUnknownNCT05520684

Trabzon Arakli Bayram Halil Public Hospital120 enrolled

Overview

The SGLT2 inhibitors have changed the treatment of type 2 diabetes mellitus in recent years, especially in patients with cardiovascular or renal disease. However, the association between SGLT2 inhibitors and urinary tract infection (UTI) risk is controversial. Moreover, it is not known whether asymptomatic bacteriuria or urinalysis abnormality at the initiation of SGLT2 inhibitors are risk factors for UTI in women. There is not enough data to recommend or not to recommend for performing urinalysis or urine culture test before initiation of SGLT2 inhibitors. The aim of the study is to investigate the effect of asymptomatic bacteriuria or urinalysis abnormality at the initiation of SGLT2 inhibitors on UTI risk in a prospective cohort of women with type 2 diabetes mellitus.

Study Type

OBSERVATIONAL

Enrollment

120

Conditions

Type2diabetes, SGLT2 Inhibitor, Urinary Tract Infection

Interventions

urine culture and urinalysisDIAGNOSTIC_TEST

urine culture and urinalysis

Medical Language ↔ Plain English

Inclusion Criteria: * Female * \>18 years old * Type 2 Diabetes Mellitus * Initiated SGLT2 inhibitors * Available informed consent Exclusion Criteria: * Having urinary tract or genital tract symptoms at the enrollment * Treated for urinary tract or genital tract infection in the last 3 months

Outcomes

Primary Outcomes

Urinary tract infection

Number of participants with urinary tract infection - Any urinary tract infection treated or diagnosed by the physician clinically or by testing

Time frame: 3 months

Asymptomatic Bacteriuria, Urinalysis Abnormality at the Initiation of SGLT2 Inhibitors and UTI Risk

Overview

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Central Contacts