TRADE Trial - Tree Nut Immunotherapy Route Development and Evaluation

Inclusion Criteria: * Allergic to tree nut with baseline threshold of 444 mg protein or less and provides consent, and where applicable, assent. Exclusion Criteria: 1. History of anaphylaxis to tree nut severe enough to cause shock, syncope, or intubation 2. Eosinophilic or other inflammatory gastrointestinal disease within the past 2 years 3. Severe (GINA severity class 5) or uncontrolled asthma including exacerbation within past 6 months 4. Use of biologics, other food immunotherapy or experimental treatment in past 6 months. 5. Ongoing other allergic diseases severe enough to preclude discontinuing antihistamines for 7 days prior to assessment visits 6. Pregnancy or significant medical condition (e.g., liver, kidney, gastrointestinal, cardiovascular, hematologic, or pulmonary disease; allergy to the oat-based placebo) which would put the participant at excessive risk for food allergic reactions as judged by local investigator