This study investigated whether a multifaceted approach was associated with hypnotic drug discontinuation at one month after discharge
Chronic use of hypnotic agents is prevalent in older adults, who as a result are at increased risk for certain adverse events, such as day-time drowsiness and falls. Multiple strategies to discontinue hypnotics have been tested in geriatric patients, but evidence remains scarce. Hence, we aimed to investigate a multicomponent intervention to reduce hypnotic drug use in geriatric inpatients. A before-after study was performed on the acute geriatric wards of a teaching hospital. The before cohort received usual care while intervention patients were exposed to a pharmacist-led deprescribing intervention, comprising education of health care personnel, access to standardized discontinuation regimens, active patient involvement and support of transitional care. The primary outcome was hypnotic drug discontinuation at one month after discharge.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
173
* Educational sessions were provided to the physicians and nursing staff. * Discontinuation regimens were developed. Prescribers were free to choose whether or not to actually use them. The regimens were derived from the regimen used by Petrovic et al. and encouraged a switch from any benzodiazepine to lorazepam 1 mg OD for one week followed by drug stop. Z-drugs were switched to zolpidem 5 mg OD for one week followed by drug stop. If deemed necessary, a pro re nata regimen of lorazepam 1 mg or zolpidem 5 mg for one additional week was prescribed respectively. The discontinuation regimens were incorporated into the hospital's electronic prescribing system. Furthermore, a clinical decision support system provided additional support. * Patient education sessions were provided upon enrolment and at discharge. Specific patient leaflets were used to facilitate patient education. * The patient's primary care physician and, if applicable, the nursing home were informed by phone.
all patients received comprehensive geriatric care without any systematic clinical pharmacist involvement regarding deprescribing of hypnotics. Treating physicians were not actively informed on the patient's participation in this particular study.
Hypnotic drug discontinuation at one month after discharge
Difference in hypnotic discontinuation rate between before and after group
Time frame: 1 month after discharge
Hypnotic drug use
Description of type and dose of hypnotic drug use
Time frame: 1 and 2 weeks after enrollment and at discharge (the end of the hospital stay, on average 12 days after admission)
Restart of hypnotics during hospital stay
The emergency use of hypnotics after any discontinuation attempt during hospital stay.
Time frame: From enrollment until discharge (the end of the hospital stay, on average 12 days after admission)
Safety - incidence of delirium occurence during hospital stay
During hospital stay the incidence of physician-identified delirium was assessed together with emergency use of antipsychotics
Time frame: From enrollment until discharge (the end of the hospital stay, on average 12 days after admission)
Sleep quality
Sleep quality was determined during a patient interview using the Pittsburgh Sleep Quality Index (PSQI). The PSQI concerns a validated questionnaire where a higher score signifies a worse sleep quality; a total score of 5 or more indicates poor sleep quality
Time frame: Upon inclusion, fourteen days after enrollment and one month after discharge
Fall risk
The occurrence of falls
Time frame: 1 month after discharge
Determinants for post-discharge hypnotic discontinuation
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Factors associated with hypnotic discontinuation
Time frame: 1 month after discharge