Women with breast cancer who are referred to the cardiac rehabilitation program at the Toronto Rehabilitation Institute will be invited to enrol in this observational study. Participants will take part in an established 16-week multimodal cardiac rehabilitation program (HEALTh program) at Toronto Rehabilitation Institute and outcome measures will be assessed before and after program participation to determine the effectiveness of the program in improving cardio metabolic health. Change in VO₂peak will be assessed using Cardiopulmonary Exercise Test (CPET). Traditional cardiac risk factors, lifestyle behaviours, exercise adherence, health-related quality of life, and fatigue will also be assessed.
Study Type
OBSERVATIONAL
Enrollment
100
Toronto Rehabilitation Institute
Toronto, Ontario, Canada
Cardiopulmonary Fitness
VO2peak assessed using cardiopulmonary exercise test
Time frame: post-intervention (16 weeks)
Visceral adipose tissue
Measured only in a subset (n=30) of participants via 1.5T MRI.
Time frame: post-intervention (16 weeks)
Left ventricular ejection fraction
Measured only in a subset (n=30) of participants via 1.5T MRI.
Time frame: post-intervention (16 weeks)
Native myocardial T1 time
Measured only in a subset (n=30) of participants via 1.5T MRI.
Time frame: post-intervention (16 weeks)
Left ventricular mass
Measured only in a subset (n=30) of participants via 1.5T MRI.
Time frame: post-intervention (16 weeks)
lipid profile
Assessed via fasting blood draw
Time frame: post-intervention (16 weeks)
Fasting glucose
Assessed via fasting blood draw
Time frame: post-intervention (16 weeks)
hemoglobin A1c
Assessed via fasting blood draw
Time frame: post-intervention (16 weeks)
Cancer-specific, health-related quality of life
Functional Assessment of Cancer Therapy (FACT) questionnaire. Minimum score = 0, maximum score = 108, with higher score representing better quality of life.
Time frame: post-intervention (16 weeks)
Depressive symptoms
Patient Health Questionnaire 9 scale. Minimum value = 0, maximum value = 27, where higher score represents more depressive symptoms.
Time frame: post-intervention (16 weeks)
Psychosocial Stress
Perceived Stress Scale (PSS). Minimum value = 0, maximum value = 56, where higher score represents more perceived stress.
Time frame: post-intervention (16 weeks)
Cancer-related fatigue
Fatigue sub-scale of the Functional Assessment of Cancer Therapy (FACT) questionnaire. Minimum score = 0, maximum score = 52, with higher score representing less fatigue.
Time frame: post-intervention (16 weeks)
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