Efficacy and Safety of Ciprofol in Laparoscopic Sleeve Gastrectomy

Inclusion Criteria: * 18 \< age ≤ 65, regardless of gender; * ASA is classified as grade I-III; * BMI≥35kg/m2 * Obese patients who need laparoscopic sleeve gastrectomy under general anesthesia; * The subjects voluntarily participated in the trial and signed the informed consent. Exclusion Criteria: * Contraindications to general anesthesia; * Accompanied by infectious heart disease such as myocarditis or endocarditis, septicemia; * Brain injury, possible intracranial hypertension, cerebral aneurysm, cerebrovascular accident history and central nervous system diseases: mental system diseases (schizophrenia, mania, insanity, etc.) and long-term history of taking psychotropic drugs, or other diseases that hinder the measurement of BIS value; * Acute heart failure, unstable angina pectoris, myocardial infarction within 6 months before screening, resting ECG heart rate ≤ 50 beats / min, third degree atrioventricular block and other serious arrhythmias, serious heart valve disease, QTc: male ≥ 450ms, female ≥ 470ms; * Abnormal liver and kidney function (ALT or AST ≥ 2.5 times the upper limit of normal value, TBIL ≥ 1.5 times the upper limit of normal value), abnormal renal function (bun or urea ≥ 1.5 times the upper limit of normal value, cr\> the upper limit of normal value, or dialysis treatment within 28 days before operation), or obvious abnormal coagulation function (pt/ aptt/tt higher than the upper limit of normal value), anemia or thrombocytopenia (HB ≤ 90g/l, PLT ≤ 80 × 109/L) * Those whose blood pressure was not satisfactorily controlled (SBP ≥ 160mmhg and / or DBP ≥ 100 mmHg in sitting position during screening period); * SBP in sitting position during screening period ≤ 90mmHg; * Diabetes subjects whose blood glucose was not satisfactorily controlled (fasting blood glucose ≥ 11.1mmol/l in the screening period and / or random blood glucose ≥ 13.6 mmol/l); * Have a history of drug abuse and alcoholism within 2 years before the screening period. Alcoholism is defined as regular drinking for more than 14 times / week (once =150 ml wine or 360 ml beer or 45 ml spirits); * The subjects who were judged to have difficulty in respiratory management were rated as grade IV by modified Mahalanobis score; * Known or suspected allergy or contraindication to various components of the study drug or other benzodiazepines, opioids, propofol, muscle relaxants, etc; * Pregnant or lactating women or subjects with birth plan within 6 months (including men); * Those who participated in any clinical trial as subjects within 3 months before enrollment; * Other circumstances determined by the researcher as unsuitable for inclusion.