Intravitreal Topotecan in the Repair of Rhegmatogenous Retinal Detachment with Proliferative Vitreoretinopathy

To be enrolled, patients need to meet the following inclusion criteria: 1. patients aged 18 years and older 2. patients who undergo PPV and/or SB for recurrent RRD due to PVR 3. patients with RRD and PVR grade C or D 4. patients who have failed standard of care surgery for RRD in the same eye previously. In order to satisfy this inclusion criterion, patients need to have previously received at least one vitreoretinal surgery for RRD, including pneumatic retinopexy, pars plana vitrectomy and/or scleral buckle, and to have clinical documentation supporting re-detachment of the retina after one or more vitreoretinal surgeries for RRD in the same eye. This cohort of patients is expected to have an extremely guarded visual prognosis and visual potential. 5. patients who are voluntarily able and willing to participate Patients undergoing combined phacoemulsification and PPV and/or SB will also be included. Any surgical technique will be considered, including relaxing retinotomy or retinectomy during PPV. The following subject exclusion criteria will be considered: 1. patients with a history of tractional or exudative retinal detachment 2. patients with severe non-proliferative or proliferative diabetic retinopathy 3. patients with other planned ocular surgery following PPV 4. patients with primary RRD 5. female patients of childbearing age (i.e. less than 50 years old). 6. patients with pre-existing bone marrow suppression or cytopenias 7. patients with pre-existing interstitial lung disease (ILD) Any other medications or treatments, including rescue therapy, will be permitted before and/or during the trial.