Study to Evaluate the Safety and Pharmacokinetics of ALMB-0166 in Patients With Acute Spinal Cord Injury

Inclusion Criteria: * Male or female, 18-75 years old. * ASIA (American Spinal Injury Association) impairment scale grade B or C. * Spinal cord injury at the cervical and thoracic level (C4-T12). * Scheduled to undergo a spinal surgery within 72 hours after the initial injury. * Acute spinal cord injury that requires surgery as judged by the investigator. * Ability to understand the entire process of this study, voluntarily participate and sign written informed consent form. * Female patients with childbearing potential must have a negative serum pregnancy test and must be non-lactating. Male patients with female partners of childbearing age and female patients in childbearing age must use a medically approved contraceptive method during the study period and for 3 months after the administration. Male patients must avoid donating sperm during the study period. Exclusion Criteria: * Surgical treatment is not necessary or impossible according to the judgment of the investigator or for other reasons. * Penetrating spinal cord injury or complete spinal cord rupture. * Accompanying traumatic brain injury (TBI) with visible structural lesions or diagnostic images, such as intracranial hemorrhage. * Patients with acute and chronic diseases that have caused neurological deficits (e.g., multiple sclerosis, Guillain-Barré syndrome, etc.) * Body temperature is lower than 35℃. * Patients with hemoglobin level \<90 g/L. * Difficulty in completing the study due to coma, mental illness or other reasons. * History of drug abuse or dependence. * Allergies to macromolecular drugs or a previous history of severe drug allergies. * Positive serology for HIV and syphilis or active Hepatitis B or Hepatitis C. * History of serious diseases of other organ systems such as heart, lungs, liver, or kidneys, who are judged by the investigator to be unsuitable to participate in clinical trials; for example, cardiovascular disease such as New York Heart Association (NYHA) Grade II or higher congestive heart failure, unstable angina pectoris, myocardial infarction, etc., and pulmonary fibrosis or interstitial lung disease, etc. within 6 months before the administration. * Patients with active malignant tumour, or a history of treatment for invasive tumours within 3 years. Patients with stage I tumours who have received definite local treatments and are considered unlikely to recur can be accepted. Patients with a history of treatment for carcinoma in situ (such as non-invasive) and a history of non-melanoma skin cancer can be accepted. * Participated in other clinical trials and received drug treatment within 30 days before enrolment. * Patients with contraindications to lumbar puncture. * Any other issue which, in the opinion of the investigator, made the patient unsuitable for study participation.