This is a randomized placebo- and active-controlled trial for assessing the efficacy of bright light therapy for sleep and mood symptoms in patients with Parkinson's disease
The primary aim of this study is to compare the efficacy of timed-BLT (BLT group) in reducing excessive daytime sleepiness in patients with Parkinson's disease, when compared to a timed-inactivated negative ion generator (active-control group). The secondary aims of the study are to examine the effect of timed-BLT on other non-motor symptoms, including depression, fatigue; and the quality of life. Additional analyses will be carried out to examine the efficacy of the timed-placebo as compared to the random-time placebo (placebo group).
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
69
Regularly-timed exposure to 10,000lux bright light therapy for 60minutes a day for six weeks
Regularly-timed exposure to an inactivated negative ion generator for 60minutes a day for six weeks
Randomly-timed exposure to an inactivated negative ion generator for 60minutes a day for six weeks
The Chinese University of Hong Kong
Hong Kong, Hong Kong
Change of daytime sleepiness
Change in the score of Epworth Sleepiness Scale (ESS), ESS score ranges from 0-24, higher score indicates greater sleepiness
Time frame: at the end of 6-week treatment
Change of depressive symptoms
Change in the score of Montgomery-Åsberg Depression Rating Scale (MADRS), MARDS ranges from 0-60, higher score indicates greater severity of depressive symptoms
Time frame: at the end of 6-week treatment
Change in fatigue symptoms
Change in the score of Faitgue Severity Scale (FSS), FSS consists of 9 items and each as rated on a scale from 1-7, higher score indicates greater severity of fatigue
Time frame: at the end of 6-week treatment
Change in quality of life
Change in score of Short-Form 12-item (SF-12) scale. SF-12 consists of two subscales - a mental component score (MCS-12) and a physical component score (PCS-12), a higher score indicates better quality of life. Scores range from 0 to 100, with higher scores indicating better physical and mental health functioning
Time frame: at the end of 6-week treatment
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