Fibrinogen plays an important role in the coagulation cascade. Low levels of preoperative fibrinogen have been associated in adults with higher blood and transfusion requirements during surgery. Guidelines from the European Society of Anesthesiology and Intensive Care recommends fibrinogen substitution based on viscoelastic tests in adult cardiac surgery. Cardiopulmonary bypass results in a profound hemodilution and dilution of all coagulation factors. This is especially true in children where the priming volume of the cardiopulmonary bypass circuit is much higher compared to the patient's weight than in adults. Cardiopulmonary bypass generates high levels of tissue plasminogen activator resulting in a hyperfibrinolysis, further lowering fibrinogen levels. The aim of this retrospective study is to explore a possible relationship between preoperative fibrinogen levels and perioperative blood loss, as well as transfusion requirements in children undergoing cardiac surgery.
Study Type
OBSERVATIONAL
Enrollment
932
All children who underwent congenital cardiac surgery with cardiopulmonary bypass between 2008 and 2018
Hôpital Universitaire des Enfants Reine Fabiola
Brussels, Belgium
Blood loss
Blood loss in mL during surgery and postoperatively during the first 24h (day 0) will be extracted from our database
Time frame: Day 0
Transfusion requirements
Transfusion requirements of packed red cells ( in mL), fresh frozen plasma (in mL) and platelets (in mL) during the first 24h (day 0) will be extracted from our database
Time frame: Day 0
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