A Study of Thalidomide in the Treatment of Refractory Uremic Pruritus

Inclusion Criteria: * Maintenance hemodialysis patients (≥3 month), 3 times/week, 4 hours/session * spKT/V≥1.2 * The diagnosis was refractory urmia pruritus and pruritus score ≥8 score * Patients with sleep disorders need to stop sleeping pills * Be able to complete the form by yourself or with the help of others * Informed consent Exclusion Criteria: * Participants in other clinical trials within 1 month * People with thalidomide allergy * Accompanied by severe calcium and phosphorus metabolism disorder (serum calcium≥3.0mmol/L or Serum phosphorus≥2.8mmol/L or Serum iPTH≥800pg/mL) * Patients with other medical conditions that cause itchy skin * With severe systemic infection, severe anemia and other serious complications * Patients with peripheral neuropathy * Other serious systemic diseases include systemic lupus erythematosus, multiple myeloma, thrombotic microangiopathy, and extensive metastasis of malignant tumors * Patients with a history of thromboembolism were excluded from PICC-induced thrombosis * Pregnant woman