The purpose of this study is to investigate how gut hormones and brain areas respond differently to gastric distention, tasteless calories, or palatable food and how this alters appetite.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
SUPPORTIVE_CARE
Masking
NONE
Enrollment
15
MRI's will be performed at multiple points on each visit day.
Intragastric Balloon will be placed during Visit 2 study day and inflated to maximum tolerated volume. Patient will then be scanned in the MRI.
Patient will ingest the tasteless elemental meal until their maximum level of fullness. Once full, the patient will be scanned in the MRI.
Mayo Clinic Rochester
Rochester, Minnesota, United States
RECRUITINGDifference in Cerebral Blood Flow related to hypothalamus
The mean difference in cerebral blood flow (CBF) at fullness (satiation) and return to hunger (satiety) to the hypothalamic area.
Time frame: 1 month
Cerebral Bloodflow related in multiple brain areas
The mean difference in cerebral blood flow (CBF) at fullness (satiation) and return to hunger (satiety) to the other brain areas related to food intake regulation.
Time frame: 1 month
Cerebral Blood Flow between three stimuli
The mean difference in cerebral blood flow (CBF) between the 3 different stimuli.
Time frame: 1 month
Hormone level
Differences in hormones levels (ghrelin, GLP-1, CCK, PYY, leptin, insulin, GIP, amylin) at each of the stages (I.e., baseline, fullness, maximal fullness) after the three different stimulations. These hormones will be compared before and after the same stimulation days. The hormone measurements on stimulation days will also be compared to each other.
Time frame: 1 month
comparison of calories
Correlation the caloric consumption to fullness, maximal fullness with degree of cerebral blood flow(CBF) change on PASL MRI.
Time frame: 1 month
calorie corellation to hormones
Correlation the caloric consumption to fullness, maximal fullness with changes in the hormonal levels (ghrelin, GLP-1, CCK, PYY, leptin, insulin, GIP, amylin).
Time frame: 1 month
hormone level comparison
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Patient will ingest meal of their choice from a local food delivery service and eat until they reach their maximum level of fullness. Once full, the patient will be scanned in the MRI
Differences in the hormonal levels (ghrelin, GLP-1, CCK, PYY, leptin, insulin, GIP, amylin) between fullness and hunger after the three different stimulations. These hormones will be compared before and after the same stimulation days. The hormone measurements on stimulation days will also be compared to each other.
Time frame: 1 month
Time differences in stimuli
Differences in time to next meal after maximal fullness after the three different stimulations.
Time frame: 1 month
Caloric consumption differences in stimuli
Differences in the caloric consumption after maximal fullness after the three different stimulations.
Time frame: 1 month
FitBit measured Physical Activity
Measurement of daily physical activity during free-living conditions measured through the use of FitBit tracker over the duration of the study.
Time frame: 1 month