α-Synucleinopathy is a cluster of neurodegenerative disease with motor and non-motor symptom. The data to be collected is intended to help healthcare providers make important medical decisions concerning α-synucleinopathy, through an enhanced understanding of the natural history, progression and multi-omics datasets of α-synucleinopathy.
α-Synucleinopathy is a cluster of neurodegenerative disease with motor and non-motor symptom, including Parkinson's disease (PD), multiple system atrophy (MSA) and dementia with lewy bodies (DLB). The data to be collected is intended to help healthcare providers make important medical decisions concerning α-synucleinopathy, through an enhanced understanding of the natural history, progression and multi-omics datasets of α-synucleinopathy. Datas will be accumulated retrospectively at research entry and prospectively during follow up.
Study Type
OBSERVATIONAL
Enrollment
500
Neuropsychological assessment, brain MRI, electroencephalogram and biomarker datas will be collected
Neuropsychological assessment, brain MRI, electroencephalogram and biomarker datas will be collected
Fujian Medical University Union Hospital
Fuzhou, Fujian, China
RECRUITINGUPDRS /UMSARS scores
Disease severity was evaluated by the neurologist using the united Parkinson's disease rating scale (UPDRS) or united multiple system atrophy rating scale (UMSARS) separately as diagnosed.
Time frame: Baseline
H&Y stage
The Hoehn and Yahr （H\&Y)
Time frame: Baseline
MoCA scores
The Montreal Cognitive Assessment (MoCA)
Time frame: Baseline
ACE-III scores
Addenbrooke's Cognitive Examination (ACE) score
Time frame: Baseline
Mean arterial pressure after 3 minutes of upright posture versus decubitus position (mmHg)
Mean arterial pressure was calculated as ⅓ pulse pressure + diastolic pressure.
Time frame: Baseline
HRV (ms)
Heart rate variability (HRV) was calculated as the maximum bpm - minimum bpm.
Time frame: Baseline
Plasma α-synuclein levels (ng/ml)
Time frame: Baseline
Vic
The intra-cellular compartment (Vic) of the Neurite Orientation Dispersion and Density Imaging (NODDI) model represents diffusion within the axons and cells.
Time frame: Baseline
PAF (Hz)
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The alpha-peak frequency (PAF) is the frequency with the highest power within the alpha-band.
Time frame: Baseline
Vic
The intra-cellular compartment (Vic) of the Neurite Orientation Dispersion and Density Imaging (NODDI) model represents diffusion within the axons and cells.
Time frame: 1 year after Baseline