This is a pilot sub-study of an ongoing trial comparing N2O to midazolam in MDD and will examine neuroimaging correlates of treatment response.
Magnetic resonance imaging (MRI) scans of MDD-affected brains have revealed changes in structural and functional connectivity compared to healthy subjects. This pilot sub-study examines structural and functional connectivity associated with MDD-affected patient participants' responsiveness to N2O compared to the midazolam placebo, which induces similar sedative effects. The investigators intend to address the changes in brain functional activity and connectivity between baseline and after a four-week intervention course involving weekly nitrous oxide inhalations measured by MRI.
Study Type
OBSERVATIONAL
Enrollment
11
This sub-study does not have an intervention and based on the main study the participants who have received N2O will be compared with the midazolam placebo group.
This sub-study does not have an intervention and based on the main study the participants who have received N2O will be compared with the midazolam placebo group.
St. Michael's Hospital
Toronto, Ontario, Canada
Brain functional activity and connectivity
Changes in brain functional activity and connectivity between baseline and after 4 weeks of receiving the intervention, measured by MR imaging.
Time frame: 4 weeks from the baseline visit
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