Cardiac Surgery and Postoperative Organ Dysfunction

The Second Affiliated Hospital of Chongqing Medical University100 enrolled

Overview

The aim of the study is to identify the correlation between ischaemia reperfusion injury and postoperative multiorgan damage during cardiopulmonary cardiac surgery; and to investigate biomarkers that can predict postoperative organ damage in cardiac surgery.

This study proposes to observe multi-organ functional impairment of the heart, kidney and brain after extracorporeal circulation in a prospective study of clinical patients; to obtain markers with diagnostic and predictive efficacy by collecting pre and postoperative serum and heart and ear tissue samples from patients with postoperative organ functional impairment, performing combined proteomic and metabolomic analyses, and by analysing them with detailed postoperative clinical prognostic data using machine learning algorithms.

Study Type

OBSERVATIONAL

Enrollment

100

Conditions

Postoperative Complications

Interventions

ischemic reperfusion injuryPROCEDURE

ischemic reperfusion injury is a pathological process in which the ischemic myocardium is restored to normal perfusion, but the tissue damage is progressively aggravated when the coronary artery supply is completely blocked after cardiopulmonary bypass surgery and then recanalised at a certain time.

Eligibility

Sex: ALLMin age: 50 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Age ≥50 years; patients requiring mitral valve replacement surgery or mitral valve plus aortic valve replacement under cardiopulmonary bypass 2. Agreed to participate in this study, and signed the informed consent form. Exclusion Criteria: 1. History of neurological disease (stroke, reversible ischemic hypoxia, transient ischemic attack, or Neurodegeneration) ; 2. Patients with severe preoperative renal insufficiency (serum creatinine \> 442 μmol/L or need renal replacement therapy) , 3. liver dysfunction (Child-Pugh grade C) 4. myocardial infarction within 4 weeks 5. ASA grade ≥ V

Locations (1)

The second affiliated hospital of Chongqing medical university

Chongqing, China

Outcomes

Primary Outcomes

incidence of postoperative cardiac injury

troponin I will be tested before and after surgery

Time frame: from the ending of surgery to 7 days after surgery

incidence of postoperative acute kidney injury

renal function will be tested before and after surgery

Time frame: from the ending of surgery to 7 days after surgery

incidence of postoperative brain injury

deliriumwill be tested before and after surgery

Time frame: from the ending of surgery to 7 days after surgery

Secondary Outcomes

Incidence of postoperative arrhythmia events

postoperative arrhythmia events are recorded according to follow-up visits after surgery

Time frame: from the ending of surgery to 72 hours after surgery

Central Contacts

Qiao Guo, MD

CONTACT

13637870013 guoqiao@cqmu.edu.cn

Dagang Wang, MD

CONTACT

+86 023 63693014 kuanrenlunli@qq.com

Data from ClinicalTrials.gov

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