Effect of Storage Condition on CD47 Expression Level in Platelet Concentrate

Assiut University1 enrolled

Overview

Effect of storage condition on CD47 expression level in platelet concentrate

CD47 is a cell surface glycoprotein expressed on all cell types .It is an attractive target for therapy because it is involved in regulation of cell survival and cell death by acting as a ligand for signal-regulatory protein alpha expressed on macrophages

Study Type

OBSERVATIONAL

Enrollment

Conditions

Platelet Storage Pool Deficiency

Eligibility

Sex: ALLMin age: 18 YearsMax age: 45 Years

Medical Language ↔ Plain English

Inclusion Criteria: * donors met AABB criteria Exclusion Criteria: * donors not met AABB criteria

Outcomes

Primary Outcomes

Assessment of CD47 expression level on platelets by exposure to different storage temperatures

To increase survival time of platelets

Time frame: 3 years

Data from ClinicalTrials.gov

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