Acanthosis nigricans (AN) is increasing in its prevalence and is the most prevalent cutaneous manifestation in individuals with obesity. Insulin resistance or hyperinsulinemia is the main pathophysiological mechanism of obesity-related AN. However, the effect of laparoscopic sleeve gastrectomy (LSG) on insulin secretion pattern in Chinese morbidly obese patients with AN is unknown. In these study, the investigators aimed to explore the insulin secretion patterns in Chinese morbidly obese patients with Acanthosis nigricans (AN) and their alterations after LSG.
Study Type
OBSERVATIONAL
Enrollment
138
LSG
Shanghai Tenth People's Hospital
Shanghai, China
RECRUITINGObesity
It was defined as BMI ≥ 28 kg/m2 according to the diagnostic criteria for obesity in a Chinese population.
Time frame: 2017-2023
A quantitative scale of Acanthosis Nigricans (AN)
0-absent: not detectable on close inspection; 1-present: clearly present on close visual inspection, not visible to the casual observer, extent not measurable; 2-mild: limited to the base of the skull, does not extend to the lateral margins of the neck (usually \<3 inches in breadth); 3-moderate: extending to the lateral margins of the neck (posterior border of the sternocleidomastoid, usually 3-6 inches), should not be visible when the participant is viewed from the front; 4-severe: extending anteriorly (\>6 inches), visible when the participant is viewed from the front.
Time frame: 2017-2023
Insulin secretion patterns
they were derived from the peak time of insulin secretion during OGTT: Type I (peak time at 30 or 60 min) and Type II (peak time at 120 or 180 min).
Time frame: 2017-2023
BMI
It was calculated as weight (kg) divided by squared height (meters).
Time frame: 2017-2023
a 2-h 75-g oral glucose tolerance test (OGTT)
It was performed after an overnight fasting in each patient pre- and 12 months pro-LSG, and blood samples were taken at 0, 30, 60, 120, and 180 min to determine the concentrations of plasma glucose and insulin.
Time frame: 2017-2023
HOMA-IR
It was calculated as FPG (mmol/L)×FINS (mU/L)/22.5 (24).
Time frame: 2017-2023
Insulin sensitivity
It derived from the OGTT was estimated by the oral glucose insulin sensitivity (OGIS) index
Time frame: 2017-2023
Insulinogenic index (IGI)
It was calculated as :(insulin30min-insulin0min)/ (glucose30min-glucose0min).
Time frame: 2017-2023
the disposition index (DI)
It was calculated as IGI/HOMA-IR.
Time frame: 2017-2023
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