Measure the Serum Level of Homocysteine in Acne Patients Before and After Oral Isotretinoin.

Aswan University60 enrolled

Overview

Serum homocysteine level in Acne patients before and after oral Isotretinoin and Correlation between serum level of homocysteine in acne patients before and after Oral isotretinoin treatment

Acne vulgaris is a common chronic inflammatory disease of the skin. It is found in about 80% of young adults and adolescents. It is a disease that affects the pilosebaceous units of the skin and may result in inflammatory or non-inflammatory lesions,Oral isotretinoin (13-cis-retinoic acid) is the only drug that counteracts all the pathogenetic mechanisms that contribute to the development of acne The standard dose of isotretinoin is 0.5 to 1 mg/kg per day for 4 months to a cumulative dose of 120-140 mg/kg is effective in the management of acne vulgaris The scope of our study is to detect serum homocysteine level in acne patient befor and after oral isotrtinoin treatment

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

DIAGNOSTIC

Masking

DOUBLE

Enrollment

Conditions

Acne Vulgaris

Interventions

IsotretinoinDRUG

Isotretinoin is a vitamin-A derivative for treatment of moderate to severe acne used in a dose from 20-40 mg for 3 months duration

Eligibility

Sex: ALLMin age: 15 YearsMax age: 45 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients of both sexes with acne vulgaris Exclusion Criteria: * Patients with history of malignancies. * Patients with renal and hepatic dysfunction. * Cardiac patient. * Pregnant, lactating and female welling to have pregnancy in the period of study. * Patient with absorption disorder. * Patient with history of favism. * Patient has already been treated with isotretinoin.

Locations (1)

Aswan University-Faculty of Medicine

Aswān, New Aswan City, Egypt

Outcomes

Primary Outcomes

Evaluation of the effect of oral isotretinoin on Serum homocysteine in acne vulgaris patients

Assessment in serum level homocysteine level in acne vulgaris patients after isotretinoin therapy with assesment of its level before starting therapy for detecting changes in serum homocysteine and effect of isotretinoin therapy on it.

Time frame: 3 months

Data from ClinicalTrials.gov

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