Nano-rheological Biomarkers for Patients With Sickle Cell Disease (SCD) Versus Control Subjects (Other Constitutional Red Blood Cell Diseases and Healthy Subjects)

Inclusion Criteria for healthy volunteers : 1. Patient age ≥ 18 years 2. With social care protection 3. Living donor recruited for kidney donation with normal blood count Inclusion Criteria for SDC patient : 1. Patient age ≥ 18 years 2. With social care protection 3. SCD patient with documented phenotype: SS, S°, S+, SC, SLepore, SOrab, SDPundjab, ASantilles... with or without specific treatment Inclusion Criteria for patient with a constitutional non-sickle cell disease of the red blood cell, or an acquired red blood cell disease : 1. Patient age ≥ 18 years 2. With social care protection 3. With any of the following conditions : 1. Patient being managed for anemia due to martial deficiency, and prior to oral or intravenous replacement therapy 2. Patient being followed for myeloproliferative syndrome at diagnosis, and prior to any specific treatment (hemodilution or hydroxycarbamide or other specific treatment) 3. A patient with a MCGRE other than a major sickle cell syndrome, whether or not under specific treatment 4. Hemoglobinopathy: transfusion-dependent or independent thalassemias (major or intermediate), thalassemias minor, heterozygous sickle cell trait A/S, other heterozygous hemoglobin variants (C, E, Lepore...), hyperaffine hemoglobin 5. Membrane disorders (hereditary spherocytosis) 6. Canalopathies (stomatocytosis with dehydrated or hyperhydrated erythrocytes, melanesian ovalocytosis...) 7. Enzyme deficiencies (G6PD, PK, GPI...) Exclusion Criteria for all patients: 1. Patient age \< 18 years 2. Subject under guardianship, or subject deprived of freedom 3. Linguistic or literacy status not allowing for informed consent despite patient information in "Easy to Read and Understand" format 4. Known history of HIV, HTLV, syphilis, or positive serology and active viral hepatitis B or C. Additional Exclusion Criteria for healthy volunteers : 5. Abnormal blood count, or possible martial deficiency with ferritin levels below 50µg/l, or current treatment with hydroxycarbamide, or transfusion within 4 months prior to inclusion. Additional Exclusion Criteria for SCD patient : 5\) Treatment with hydroxycarbamide started less than 6 months ago 6) Anemia with hemoglobin level \<60g/l in the absence of cardiorespiratory pathology, \<70g/l in pregnancy, or in the presence of cardiorespiratory pathology that may alter the tolerance of anemia. Additional Exclusion Criteria for patient with a constitutional non-sickle cell disease of the red blood cell, or an acquired red blood cell disease : 5\) Anemia with hemoglobin level \<60g/l, \<70g/l in pregnancy, or in the presence of cardio-respiratory pathology that may alter the tolerance of anemia. 6\) Diagnosis not finalized (in progress), or uncertain nosological framework, or diagnostic wandering.