Colorectal cancer (CRC) has become one of the most common malignant tumors in the world, and the key to its prevention and control is early detection and treatment. As colorectal adenoma and inflammatory bowel disease (IBD) are the inevitable precursors of most CRC, screening for colorectal adenoma and IBD is of great importance for preventing CRC. The existing detection methods have high sensitivity for CRC, while limited in colorectal adenoma and IBD. Therefore, exploring a detection method with high sensitivity for colorectal adenoma and IBD is necessary. This project intends to use methylation detection technology, lactic acid modified omics, proteomics, metagenomics, and other omics technology, through the analysis of differences in feces and histological results in healthy volunteers, patients with non-advanced adenoma, patients with advanced adenomas, patients with IBD, and patients with CRC for early screening.
Study Type
OBSERVATIONAL
Enrollment
500
Changhai Hospital, Naval Medical University
Shanghai, China
RECRUITINGDetection of advanced colorectal adenoma
An advanced colorectal adenoma is defined as a colorectal adenoma ≥10 mm, adenoma with tubulovillous or villous histology, or adenoma with high-grade dysplasia
Time frame: Through study completion, an average of 1 year
Detection of colorectal cancer
Lesions will be confirmed as malignant by histopathologic examination.
Time frame: Through study completion, an average of 1 year
Detection of non-advanced colorectal adenoma
A non-advanced colorectal adenoma is defined as tubular adenoma less than 1cm in diameter.
Time frame: Through study completion, an average of 1 year
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