Characterization of Enterococcus Faecalis Endocarditis and Impact of Amoxicillin MIC Elevation on Patient Outcome

Fondation Hôpital Saint-Joseph281 enrolled

Overview

Infective endocarditis is a complex infection that can be life-threatening. These infections also cause anatomical lesions that can be severe. Their management is complex and involves several disciplines: cardiology, bacteriologists, infectious diseases specialists, radiologists, nuclear medicine specialists, cardiac surgeons, neurologists, pharmacologists, etc. The incidence of Enterococcus faecalis endocarditis is increasing due to the aging of the population and the disappearance of rheumatic fever. The adequate management of these infections is complex and relies on the prolonged administration of high-dose antibiotics, classically the combination of amoxicillin and ceftriaxone. In the context of Streptococcal endocarditis, the impact of increasing the Minimum Inhibitory Concentration (MIC) of amoxicillin on patient mortality has been demonstrated but no study has yet examined the impact of increasing the MIC of amoxicillin on the outcome of patients treated for Enterococcus faecalis infective endocarditis.

Study Type

OBSERVATIONAL

Enrollment

281

Conditions

Infectious Endocarditis

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patient over 18 years of age with a diagnosis of Enterococcus faecalis infective endocarditis based on Duke criteria * Patient hospitalized in one of the participating centers * French-speaking patient Exclusion Criteria: * Patient with suspected infective endocarditis who does not meet Duke criteria * Patient under guardianship or curatorship * Patient deprived of liberty * Patient under court protection * Patient objecting to the use of their data for this research

Locations (2)

Outcomes

Primary Outcomes

Describe the epidemiology and clinical presentations of patients with Enterococcus faecalis endocarditis

This outcome corresponds to the evaluation of factors associated with mortality in patients with Enterococcus faecalis endocarditis.

Time frame: Month 1

Secondary Outcomes

Impact of increasing the minimum inhibitory concentrations of amoxicillin on the outcome of Enterococcus faecalis infective endocarditis

This outcome corresponds to the description of the epidemiology of Enterococcus faecalis endocarditis in France.

Time frame: Month 1