Effects of Peanut Intake on Cognitive Functions

N/ACompletedNCT05532007

Loma Linda University30 enrolled

Overview

The study will test the effects of Peanuts on task-related brain activation and cognitive functions in older adults with memory complaints.

The purpose of the study is to determine the effects of peanuts on cognitive performance and task-related brain activation on functional magnetic resonance imaging (fMRI) in older adults. The specific aim of the study is to explore the neuroprotective effects of a peanut-enriched diet (2-3 oz of peanuts to replace 20% of the total energy of the habitual diet) for 12 weeks compared to a peanut-excluded habitual diet in elderly men and women with increased risk for CVD and self-reported memory complaints. The study population is older adults 60-80 years in age.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Enrollment

Conditions

Cognition Inflammation

Interventions

PeanutsDIETARY_SUPPLEMENT

2-3 ounces of peanuts to replace 20% of total daily energy intake

Habitual DietOTHER

continue with habitual diet and abstain from eating peanuts

Eligibility

Sex: ALLMin age: 60 YearsMax age: 80 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Non-demented elderly between 60-80 years of age * Self-reported memory complaints * Two cardiovascular risk factors * Stable weight for at least 6 months prior to recruitment Exclusion Criteria: * Peanut allergy * Smoker * Endocrine, metabolic and neuropsychological disorders * Ineligible to get an MRI * Consuming more than 3 servings/week of nuts including peanuts

Locations (1)

Loma Linda University School of Public Health

Loma Linda, California, United States

Outcomes

Primary Outcomes

changes from baseline in Brian activation

Changes will be assessed by Functional MRI (fMRI) on participants. there is no units of measure

Time frame: baseline to 12 weeks

changes from baseline serum markers of inflammation

changes in serum inflammation markers which includes hs-CRP, IL-6, TNF-α, ICAM/VCAM, eSelectin, F2-isoprostanes, 8-hydroxy-deoxyguanosine (8-OH-dG) will all be assessed using ELISA

Time frame: baseline to 12 weeks

Secondary Outcomes

changes from baseline in global cognitive composite score

The composite score will be calculated using the scores from the tests listed below. We will calculate the standardized scores of each test as the score of each participant minus the group mean and divide by its standard deviation. The composite score is the mean of the standardized scores. the 5 tests are: Rey Auditory Verbal Learning Test (RAVLT), Brief Visuospatial Memory Test, Digit Span, FAS Word Fluency, Symbol Digit Modalities Test

Time frame: baseline to 12 weeks

Change in serum brain-derived neurotrophic factor (pg/mL)

changes in serum brain-derived neurotrophic factor (pg/mL) assessed by ELISA

Time frame: baseline to 12 weeks

Data from ClinicalTrials.gov

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