Dezoxide Suppresses Sufentanil-induced Cough

Shanghai Zhongshan Hospital176 enrolled

Overview

Dizocine (0.03 mg/kg) or saline followed by sufentanil 0.4ug/kg was administered, and induction was completed with 3 min of observation. Heart rate and mean arterial pressure (MAP) were recorded before induction of anesthesia, before and 1 min after intubation, and side effects during induction, such as vomiting, hypoxemia (SpO2 \<90%), or other expected effects. The number of coughs was recorded in both groups, and the severity of cough was defined as follows: mild, 1-2 coughs; moderate, 3-4 coughs; severe, 5 or more coughs.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

TRIPLE

Enrollment

176

Conditions

Sufentanil-induced Cough

Interventions

Intravenous dizocineDRUG

Intravenous dizocine (0.03mg/kg diluted to 5 ml)

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients admitted for elective valve surgery, artificial vessel replacement or coronary artery bypass graft surgery; Age 18\~80 years old; Sex is not limited; ASA class II\~III; NYHA Class II-III; Patients or their family members have signed the clinical trial informed consent form Exclusion Criteria: * Upper respiratory tract infection within the last two weeks; Long history of smoking; chronic obstructive pulmonary disease; Highly reactive airway diseases such as bronchitis and asthma; Presence of high cranial pressure, high eye pressure, pulmonary alveolus; Malignant tumor, hematological disease, severe liver and kidney dysfunction, recent serious infection, etc.

Outcomes

Primary Outcomes

sufentanil-induced cough

rate and severity of cough after sufentanil injection

Time frame: 2 minutes after intubation

Secondary Outcomes

heart rate

heart rate during induction of general anesthesia

Time frame: 2 minutes after intubation

mean arterial pressure

mean arterial pressure during induction of general anesthesia

Time frame: 2 minutes after intubation

SpO2

SpO2 during induction of general anesthesia

Time frame: 2 minutes after intubation

Data from ClinicalTrials.gov

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