This study corresponds to a monocentric prospective cohort of adult patients with systemic sclerosis. It will allow the constitution of an organized collection of longitudinal clinical data as well as collection of biological samples, including blood samples, as well as stool sample and skin swab for microbiota analysis.
Study Type
OBSERVATIONAL
Enrollment
100
80 ml of blood samples collected at inclusion and at 18 months
A stool sample for collection of digestive microbiota at inclusion
A skin swab sample for collection of skin microbiota at inclusion and at 18 months
CHRU de Brest
Brest, France
RECRUITINGAge
To assess whether age correlates with disease profile and progression
Time frame: 5 years
Sex
To assess whether sex correlates with disease profile and progression
Time frame: 5 years
Weight
To assess whether weight correlates with disease profile and progression
Time frame: 5 years
Medical history
To assess whether medical history predicts the pattern and course of the disease
Time frame: 5 years
Family history
To assess whether family history predicts the pattern and course of the disease
Time frame: 5 years
Rodnan score
This score evaluates the thickness of the skin from 0 to 51. 0 meaning the absence of scleroderma (the healthiest score) and 51 completely sclerotic skin (the worst possible score)
Time frame: 5 years
active digital ulcers
4 characteristics must be taken into account: 1. the type of ulcer: mechanical/on calcinosis/ischemic 2. the recent/semi-recent/chronic character, 3. the painful character or not, 4. the total number of fingers affected on the 10 fingers.
Time frame: 5 years
dyspnea
* stage I: absence of dyspnea for usual efforts: no discomfort is felt in everyday life, * stage II: dyspnoea for usual heavy exertion, such as brisk or hill walking or climbing stairs (≥ 2 floors), * stage III: dyspnea for low intensity efforts of everyday life, such as walking on flat ground or climbing stairs (\< 2 floors), * stage IV: permanent dyspnea at rest or for minimal effort (putting on a garment, for example)
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At inclusion and each year for 5 years
At inclusion and 18 months
Time frame: 5 years
Free Carbon Monoxide Diffusion (DLCO)
Free Carbon Monoxide Diffusion (DLCO) in percentage.
Time frame: 5 years
6-minute walk test
Distance (in meters) covered in the 6-minute walk test.
Time frame: 5 years
systemic pulmonary arterial pressures
Measured on cardiac ultrasound.
Time frame: 5 years
SF-36 (Short-Form 36)
The SF-36 is an indicator of health status and quality of life. The SF-36 has eight dimensions; the scores are weighted sums of the questions in each section. This scores range from 0 - 100. Lower scores indicate more disability and higher scores less disability. The eight dimensions of this score are: * Vitality * Physical functioning * Bodily pain * General health perceptions * Physical role functioning * Emotional role functioning * Social role functioning * Mental health
Time frame: 5 years
BPI : Pain scale
A quick and easy way to measure the intensity of pain and its impact on daily activities. Patients rate the maximum, minimum, average and current intensity of their pain and the influence of pain on seven aspects of functional ability. 3 scores are obtained between 0 and 10, with 10 corresponding to : * the worst pain experienced in the last 24 hours * the highest pain intensity combining the most intense, the least intense, the average pain and the pain experienced at the time of the questionnaire * the highest interference of the pain on daily activities
Time frame: 5 years
HAQ- Health Assessment Questionnaire - Disability Index
Evolution of HAQ-DI (Health Assessment Questionnaire - Disability Index) during follow-up 8 fields questionnaire (DRESSING \& GROOMING, ARISING, EATING, WALKING, HYGIENE, REACH, GRIP, Other activities), scaled from 0 to 3, 3 meaning a worse outcome
Time frame: 5 years