Efficacy of Three Antiemetics in Preventing Nausea and Vomiting

The Second Affiliated Hospital of Chongqing Medical University200 enrolled

Overview

To explore the effect of commonly used antiemetic drugs on reducing nausea and vomiting caused by intravenous tramadol injection, so as to reduce the incidence of nausea and vomiting in clinical use of tramadol and provide guidance for the clinical use of tramadol injection

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

TRIPLE

Enrollment

200

Conditions

Nausea and Vomiting

Interventions

tropisetronDRUG

One tropisetron was given 30 minutes in advance, and then tramadol 1.5mg/kg was intravenously injected with a micropump at a constant speed.

metoclopramideDRUG

One dose of metoclopramide was given 30 minutes in advance, and then tramadol 1.5mg/kg was injected intravenously with a micropump at a constant speed.

dexamethasoneDRUG

One dose of dexamethasone was given 30 minutes in advance, and then tramadol 1.5mg/kg was injected intravenously with a micropump at a constant speed.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * American Society of Anesthesiologists classification I-II * 18.5≤BMI≤28 * Patients who receiving breast and thyroid surgery and requiring general anesthesia and receive PCIA * Voluntarily and be able to understand and sign the informed consent form Exclusion Criteria: * Long-term use of analgesics, psychotropic drugs (including opioids, NSAIDS, antidepressants) history * History of allergy to opioids * Patients with a history or family history of epilepsy that has not been controlled by treatment * Sedatives and antidepressants were used 24 hours before surgery * Failure to cooperate with the study for any reason or in the opinion of the investigator

Locations (1)

The Second Affiliated Hospital, Chongqing Medical University

Chongqing, Chongqing Municipality, China

Outcomes

Primary Outcomes

NRS score of nausea and vomiting

NRS score of nausea and vomiting was assessed by numerical rating scale (0-10, 0 representing no nausea and 10 the worst nausea imaginable)

Time frame: From before administration to 10min after administration

Secondary Outcomes

Incidence of postoperative nausea and vomiting

PONV is recorded according to whether the patient present nausea and vomiting during the follow-up visits after surgery

Time frame: From end of operation to 24 hours after operation

NRS score of postoperative nausea and vomiting

NRS score of nausea and vomiting was assessed by numerical rating scale (0-10, 0 representing no nausea and 10 the worst nausea imaginable)

Time frame: From end of operation to 24 hours after operation

Incidence of extra treatment for postoperative nausea and vomiting

Incidence of extra treatment for postoperative nausea and vomiting was assessed by whether patient using other treatment for postoperative nausea and vomiting during the the follow-up visits after surgery

Time frame: From end of operation to 24 hours after operation

Data from ClinicalTrials.gov

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