Assessment of Complete Response MRI Criterion After Neoadjuvant Therapy in Locally Advanced Rectal Cancer

Centre Hospitalier Universitaire de Nīmes99 enrolled

Overview

Standard care for locally advanced rectal cancer consists in a neoadjuvant therapy followed by surgery. Morbidity and mortality remain high after rectal surgery, and often linked with quality of life impairment. 10 to 30% present a pathological complete response after neoadjuvant therapy. Some surgical teams propose "watch and wait" approach for patients selected with clinical complete responses criterion. The problem is to be sur the response is complete. MRI seems to be accurate to select complete responders. We will try to find MRI criterion of complete responses.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Rectal Neoplasms

Eligibility

Sex: ALLMin age: 18 YearsMax age: 100 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Rectal adenocarcinoma * Locally advanced * Neoadjuvant therapy * MRI restaging * Rectal surgery * Definitive anatomopathology study

Locations (1)

Chu de Nîmes

Nîmes, GARD, France

Outcomes

Primary Outcomes

Complete response MRI criterion

We selected several objective MRI criterion among literature and compared them between the two groups.

Time frame: Day 0: immediately after the procedure

Secondary Outcomes

MRI accuracy

Calculated Sensitivity, Specificity, Positive Predictive Value and Negative Predictive Value.

Time frame: Day 0: immediately after the procedure