The trial evaluates the safety and efficacy of the olfactory mucosa-derived mesenchymal stem cells based therapy for the patients with chronic laryngeal and tracheal stenosis
Trial evaluating the safety and efficacy of olfactory mucosa-derived mesenchymal stem cells based therapy for the patients with chronic laryngeal and tracheal stenosis with/without cartilage defects Mesenchymal stem cells are obtained from tissue biopsy of olfactory mucosa using explant method. Biomass of autologous mesenchymal stem cells in 10% human albumin solution is injected submucosally around and over the tissue after removal of a granuloma tissue during surgical intervention.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
20
Autologous olfactory mucosa-derived mesenchymal stem cells
Patients treated according to current clinical protocols
Institute of Biophysics and Cell Engineering of National Academy of Sciences of Belarus
Minsk, Belarus
Number of patients who didn't require the repeated surgical interventions
Relative number of patients who didn't require the repeated surgical interventions after MSC therapy
Time frame: 1 year
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