Endoscopic Radiofrequency Ablation of Celiac Ganglion for Pain Management and Improvement of Quality of Life in Patients With Unresectable Pancreatic Cancer

West Virginia University12 enrolled

Overview

This study aims to evaluate the EUS-RFA in terms of efficacy for pain management and improvement in quality-of-life parameters for patients with advanced inoperable pancreatic cancer. The primary objectives of this study are to 1) evaluate the utility of EUS-RFA for pain control and improvement in quality-of-life parameters for patients with advanced pancreatic cancer; 2) to measure the reduction of analgesic medications' requirements in patients affected by inoperable pancreatic cancer.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Pancreatic Cancer

Interventions

Ablation of Celiac GanglionPROCEDURE

Endoscopic Ultrasound-guided Radiofrequency Ablation of Celiac Ganglion

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Diagnosis of pancreatic cancer based on clinical, radiological, or pathological assessment; * Referred for abdominal and/or back pain due to pancreatic cancer; * No prior history of RFA; * Cancer pain unresponsive to the WHO 3-step analgesic ladder; * Willingness to consent to participate in the study. Exclusion Criteria: * Patients who are not willing to give informed consent or agree to participate in the study * Surgically resectable pancreatic cancer; * Abdominal pain with etiology other than pancreatic malignancy; * Evidence of concurrent infection; * Patients with irreversible coagulopathy international normalized ratio \>1.5 or platelet count \<50,000/mm3), * Patients with a preliminary diagnosis of adenocarcinoma are not possible established with intraprocedural at EUS-guided FNA.

Outcomes

Primary Outcomes

Pain severity-BPI

Change in severity of pain will be assessed using a standardized the Brief Pain Inventory-Short Form (BPI) ranging from 0 (no pain) to 10 (worst pain possible).