This research aims to look at the effect of low-dose naltrexone on the severity and frequency of attacks in people with chronic migraine with or without new daily persistent headache and fibromyalgia. A few studies suggest low-dose naltrexone is effective for fibromyalgia, but it has not been studied in patients with migraine and headaches. Our goal is to see if there is an improvement in either severity and frequency of attacks and overall impact on quality of life over a three-month period.
Study Type
OBSERVATIONAL
Enrollment
30
Patients who already have a prescription for low-dose naltrexone will be administered questionnaires twice during the trial. Additionally, patients will maintain migraine diary for the duration of the trial.
Jefferson Headache Center
Philadelphia, Pennsylvania, United States
RECRUITINGEffectiveness on migraine
Monthly migraine days
Time frame: 9-12 weeks
Effectiveness on headache
Monthly headache days
Time frame: 9-12 weeks
Intensity
Average peak intensity of migraine
Time frame: 9-12 weeks
The Migraine Disability Assessment Test
Impact of migraine on daily life
Time frame: 9-12 weeks
Migraine Specific Quality of Life Index
Impact of migraine and migraine treatment on quality of life
Time frame: 9-12 weeks
Patient Health Questionnaire
Monitor depression and changes in signs/symptoms of depression
Time frame: 9-12 weeks
Fibromyalgia Impact Questionnaire
Assess health status of patients with fibromyalgia
Time frame: 9-12 weeks
Patients' Global Impression of Change
Assess patient's belief in efficacy of treatment
Time frame: 9-12 weeks
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