Sleep Disorder in Inflammatory Bowel Disease and Its Association With Disease Activity

Mahidol University100 enrolled

Overview

Recently, an association between active inflammatory bowel disease (IBD) and poor sleep quality has been proposed; however, the causal relationship has not yet been established. This study aimed to investigate prevalence of poor sleep quality in IBD and association with disease activity by subjective and objective measures. Prospective observational study is conducted with expected sample size of 100 patients. Participants are classified into active and inactive disease status according to standard IBD severity assessment measures. Demographic data, disease activity, quality of life, sleep questionnaire (validated PSQI questionaire), and seven-day sleep data acquired from ambulatory wrist actigraphy were obtained. Association between sleep quality and disease activity will be analyzed.

Study Type

OBSERVATIONAL

Enrollment

100

Conditions

Sleep Disorder Inflammatory Bowel Diseases

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age ≥ 18 years * Diagnosed inflammatory bowel disease, followed up in Siriraj hospital, Mahidol University Exclusion Criteria: * Unstable medical conditions * Known psychiatric disease * Patients who could not withhold sedative drugs * Pregnant patients * Obese patients with body mass index (BMI) ≥ 35 kg/m2 * Refuse to sign a consent/ had cognitive impairment

Locations (1)

Outcomes

Primary Outcomes

Subjective sleep quality

PSQI (Pittsburg sleep questionaire index) scores at first day then every month. PSQI contains ten questions, scoring provides sleep duration, latency, disturbance, efficiency, and quality. Total PSQI score of \> 5 indicates poor sleep quality.

Time frame: 12 months

Objective sleep quality

Sleep efficiency (percentage of total sleep time compared to time-in-bed) provided by ambulatory wrist actigraphy on first seven consecutive days and at 12-month period. Score less than 85% is considered poor sleep quality.