BUMPP: A Study to Better Understand Mood During the Perinatal Period

University of Minnesota168 enrolled

Overview

The overall goal of the BUMPP study is to improve our understanding of a range of moods, feelings, and thoughts that women can experience during pregnancy and soon after they give birth. This study will examine how these moods, feelings, and thoughts are related to changes in hormonal and immune health that women experience during and after pregnancy, and to mother-baby relationships and infant development in the early postpartum months.

Study Type

OBSERVATIONAL

Enrollment

168

Conditions

Pregnancy Postpartum Mental Health Issue

Interventions

Observation GroupOTHER

No intervention; this is an observational study.

Eligibility

Sex: FEMALEMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * 18 years or older * 35 weeks pregnant or less * carrying only one baby (not twins or triplets) * first time giving birth * can speak/read/write in English Exclusion Criteria: * major medical health condition like a heart, kidney, or liver disease or HIV * currently taking corticosteroids, progesterone, or immunosuppressive medications that might impact the samples we are taking in this research study * have regularly used alcohol, tobacco, or recreational drugs (such as marijuana or prescription drugs for non-medical reasons) during pregnancy (regularly means more than a few times total, such as on a monthly, weekly, or daily basis)

Locations (1)

University of Minnesota

Minneapolis, Minnesota, United States

Outcomes

Primary Outcomes

Self-report questionnaire measure of depressive symptoms (Edinburgh Postnatal Depression Scale)

Assessed at each of 4 sessions

Time frame: 35 weeks of pregnancy through 2 months postpartum

Self-report questionnaire measure of anxiety symptoms (Generalized Anxiety Disorder-7)

Assessed at each of 4 sessions

Time frame: 35 weeks of pregnancy through 2 months postpartum

Self-report questionnaire measure of manic symptoms (Highs Scale)

Assessed at each of 4 sessions

Time frame: 35 weeks of pregnancy through 2 months postpartum

Self-report questionnaire measure of symptoms of psychosis (subscales of Symptom Checklist-90)

Assessed at each of 4 sessions

Time frame: 35 weeks of pregnancy through 2 months postpartum

Mother-infant behavior during 5 min play episode coded using Global Rating Scales

Assessed at in-person laboratory session (session 4)

Time frame: 2 months postpartum

Bayley Scales of Infant Development, 4th edition, to assess infant cognitive development

Assessed at in-person laboratory session (session 4)

Time frame: 2 months postpartum

Secondary Outcomes

Monthly cortisol levels determined from hair sample

1 sample at session 4

Time frame: 35 weeks of pregnancy through 2 months postpartum

Cytokine levels determined from finger prick blood spot

Data from ClinicalTrials.gov

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