Even though remimazolam is known to be safely administered without hemodynamic instability, hypotension is the one of the common side effects of remimazolam. Because elderly patients are susceptible to hypotension due to old age, multimodality, and multiple medications, hypotension can be harmful in elderly patients. Remimazolam can be administered either bolus or continuous for anesthetic induction. In our study the investigators aimed to compare the incidence of hypotension after anesthetic induction using remimazolam by bolus injection and continuous infusion in elderly patients.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
TRIPLE
Enrollment
62
0.19-0.25 mg/kg for 60-80 years old 0.14-0.19 mg/kg for \>80 years old
12 mg/kg/hr until loss of consciousness
Kangbuk Samsung Hospital
Seoul, Seoul, South Korea
The incidence of hypotension
Systolic blood pressure \< 90 mmHg
Time frame: 10 minutes after intubation
The incidence of bradycardia
Heart rate \< 40 beats per minute
Time frame: 10 minutes after intubation
Number of participants with use of any vasopressors
Use of ephedrine, phenylephrine
Time frame: 10 minutes after intubation
Lowest systolic blood pressure
The lowest systolic blood pressure measured within10 minutes after intubation
Time frame: 10 minutes after intubation
Time to loss of consciousness
Time to loss of consciousness. Loss of consciousness is assessed by the loss of response to shoulder shaking.
Time frame: 10 minutes after intubation
Total remimazolam used for anesthetic induction
Sum of remimazolam used during anesthetic induction
Time frame: 10 minutes after intubation
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