In this within-subject cross-over study, the investigators hypothesize that corn-starch based supplements taken prior to exercise will decrease the risk of delayed hypoglycemia in adolescents with T1D, improve performance during exercise, and decrease glycemic variability during exercise.
Type 1 diabetes (T1D), one of the most common chronic diseases in adolescents, is caused by the destruction of insulin producing beta cells which are located in the pancreas. There are many factors that impact diabetes control which are insulin administration, intake of food and exercise. When an individual exercises, weight is better managed which allows for a better cardiovascular system. Exercising also improves insulin sensitivity which can increased the risk for delayed hypoglycemia (low blood sugar). Many individuals with T1D do not participate (or under-participate) in exercise due to the fear of hypoglycemia. This study will recruit adolescents with Type 1 diabetes to undergo a maximal exercise test to determine their VO2max. Study participants then will complete 2 exercise performance tests prior to which the participant will be randomized to consume 22 grams of either fast acting carbohydrates or long-acting cornstarch based supplements. Subjects will be asked to bike for 45 minutes (at 50% of VO2max) and then complete a 3.75 mile bike ride as quickly as possible. The investigators will document the time to completion of the bike ride as well as monitor glucose levels via continuous glucose monitoring for 12 hours after completion of the exercise test.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Pre-exercise carbohydrate, fast-acting
Pre-exercise carbohydrate, slow-acting
UB MD Pediatrics Division of Pediatric Endocrinology
Buffalo, New York, United States
Number of hypoglycemic events 12 hours after completion of exercise challenge
Review of continuous glucose monitoring data
Time frame: 12 hours after exercise challenge
Glycemic variability during exercise challenge
Review of continuous glucose monitoring data
Time frame: During exercise challenge
Time to completion of distance bike challenge
Number of minutes to complete 3.75 mile bike ride
Time frame: During exercise challenge
Percent time spent in hypoglycemia following exercise challenge
Review of continuous glucose monitoring data
Time frame: 12 hours after exercise challenge
Percent time above range, in range, and below range following exercise challenge
Review of continuous glucose monitoring data
Time frame: 12 hours after exercise challenge
Glycemic variability in the 12 hours following the exercise test
Review of continuous glucose monitoring data
Time frame: 12 hours after exercise challenge
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