Tai Chi Versus Conventional Exercise to Improve Cognitive Performance in Older Adults With Mild Cognitive Impairment

The University of Hong Kong315 enrolled

Overview

This randomized controlled trial aims to evaluate the effectiveness of Tai Chi and conventional exercise on improving cognitive function in older adults with mild cognitive impairment (MCI). Participants will be randomized into three six-month programmes, namely Health Education group, Tai Chi group and Conventional Exercise group. Assessments will be conducted at baseline, after the 26-week interventions, and 26-week after the competition of the intervention.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

315

Conditions

Mild Cognitive Impairment

Interventions

Health Education

Eligibility

Sex: ALLMin age: 50 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Chinese older adults aged equal or larger than 50 years * Ethnic Chinese * MCI under criteria of Mayo Clinic, including the following i. people with subjective complaint about a decline in cognitive function. ii. total score in the Montreal Cognitive Assessment is equal or below the 7th percentile of the age- and education- corrected normative data of Hong Kong. iii. the decline in cognitive function does not impair daily functioning, as revealed by getting ≥2 marks in every item on the Chinese Lawton Instrumental Activities of Daily Living 4-point Scale). Exclusion Criteria: * medical history of major chronic diseases such as cancer, stroke, cerebro- and cardio-vascular diseases, and renal disease * uncontrolled diabetes * diagnosed with dementia or using anti-dementia medication * diagnosed with psychiatric diseases or using psychiatric medication * with diseases or on medications known to severely affect cognitive performance * somatic condition (e.g., limb lost) that prevent participation in exercise * impaired mobility by chronic diseases (e.g., neurological, musculoskeletal and autoimmune diseases) * incapable to perform physical exercise * regular exercise habit (\>3 times 60-min Tai Chi or moderate-intensity conventional exercise weekly) in the past 3 months

Outcomes

Primary Outcomes

The score of the Montreal Cognitive Assessment (MoCA)

Change in the score of the Montreal Cognitive Assessment. The score ranged from 0 to 30. Higher score indicates a better cognitive function. Participants scoring equal or below the 7th percentile of the age- and education-corrected normative data will be considered as having MCI.

Time frame: 26 weeks

The score of the Montreal Cognitive Assessment (MoCA)

Time frame: 52 weeks

Secondary Outcomes

Clinical Dementia Rating

The Clinical Dementia Rating (CDR) is a numeric scale of 0-3 points based on clinician/ certified rater ratings of cognition and daily function in the domains of memory, orientation, judgment and problem solving, community affairs, home and hobbies, and personal care. Rating from 0, 0.5, 1, 2 and 3 indicated subjects' cognitive function having healthy, very mild impairment, mild impairment, moderate impairment and severe impairment respectively.