Multi-omics Analysis of Chronic Kidney Disease

Shanghai 10th People's Hospital150 enrolled

Overview

Chronic kidney disease (CKD) is a progressive disease with hidden epidemics and one of the most significant contributing factors to end-stage renal disease (ESRD), cardiovascular comorbidities, cachexia and anemia, which accounts for a nearly 1.2 million populations died per year.

Study Type

OBSERVATIONAL

Enrollment

150

Conditions

Potential Mechanisms Underlying the Microbiota-Gut-Kidney Axis in CKD

Interventions

renal functionBEHAVIORAL

levels of eGFR

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: Age-matched and gender-matched HC with normal renal and liver function and not taking any medications were enrolled Exclusion Criteria: 1. Age\<18 years. 2. Individuals with hypertension, diabetes, obesity, metabolic syndrome or pregnancy. 3. Individuals who received gastrointestinal operation, antibiotics or probiotic products within one month.

Locations (1)

Department of Nephrolgoy, Shanghai 10th People's Hospital

Shanghai, Shanghai Municipality, China

RECRUITING

Outcomes

Primary Outcomes

Functional and structural alteration of microbiotas and their crosstalk with CKD-associated metabolism

Gut metagenome, fecal metabolome and serum metabolome were performed in this disease-severity classified CKD cohort, to identify the changes of microbial compositions and metabolism in CKD progression

Time frame: baseline

Central Contacts

Haichao Wang

CONTACT

15316167902 whctidy@tongji.edu.cn

Data from ClinicalTrials.gov

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