Application of Hyaluronic Acid in Diabetes

Cairo University26 enrolled

Overview

sub gingival application of hyaluronic acid create great clinical improvement of periodontal pocket treatment.

To clinically and radiographically evaluate the adjunctive effect of the local application of a 0.8% hyaluronan gel in addition to scaling and root planing in treatment of controlled diabetic patients with stage II periodontitis.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Periodontal Diseases

Interventions

Hyaluronic acidDRUG

anti-inflammatory, anti-edematous, osseoinductive.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Age ≥ 18 years. * Patient with controlled diabetic type 2 (HgA1C \<7) (Mori et al., 2021). * Periodontitis stage II. * Periodontitis grade B. * Pocket depth \> 4 mm. * Smoking ≤ 10 cigarettes/day. * Cooperative patients able and accept to come for follow up appointments Exclusion Criteria: * • The use of antibiotics or anti-inflammatory drugs 1 month prior to the procedure and till the end of 6 months of follow-up. * Having surgical therapy or undergoing orthodontic treatment. * Ongoing drug therapy that might have an impact on the clinical signs and symptoms of periodontitis. * Pregnant and lactation females. * Smoking ˃ 10 cigarettes/day. * Patients with poor oral hygiene. * Any known allergies

Locations (1)

faculty of dentistry Cairo university

Cairo, Egypt

RECRUITING

Outcomes

Primary Outcomes

Clinical attachment level gain

Clinical attachment gain by using UNC15 Periodontal probe/ numerical data

Time frame: 3 months

Secondary Outcomes

Pocket depth reduction

Pocket depth reduction by using UNC15 Periodontal probe/ numerical data

Time frame: 3 moths

Bleeding on probing

Bleeding on probing by using UNC15 Periodontal probe/ binary data

Time frame: 3 months

Gingival Recession

Gingival Recession by using UNC15 Periodontal probe/ numerical data

Time frame: 3 months

Radiographic Evaluation

by using periapical radiograph with standardized acrylic stent

Time frame: 3 months

Central Contacts

Reem M Alabbadi, BDS

CONTACT

00201551563633 reem.alabbadi@dentistry.cu.edu.eg

Nesma M Shemais, PHD

CONTACT

00201005615697 nesma.shemais@dentistry.cu.edu.eg

Data from ClinicalTrials.gov

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